Abstract |
A double-masked, randomized, parallel group, placebo-controlled study demonstrated the efficacy of Naphcon-A ( naphazoline HCl 0.025% and pheniramine maleate 0.3%). Seventy-two patients with a documented positive skin test or radioallergosorbent test were recruited. Three groups of 24 patients each received 1 drop of Naphcon-A instilled in one eye, and 1 drop of either naphazoline, pheniramine, or placebo in the other eye. After the instillation of test medication, a titrated dose of ragweed antigen was administered bilaterally, and ocular signs and symptoms were evaluated 10, 30, and 120 minutes later. All patients (excluding 4 who had persistent symptoms attributable to ragweed) were rechallenged with ragweed antigen at 120 minutes to assess the duration of action of the test medications. Naphcon-A was significantly more effective than placebo, naphazoline, and pheniramine in reducing redness. Naphcon-A and pheniramine were equally effective in relieving itching.
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Authors | R J Dockhorn, T G Duckett |
Journal | Current eye research
(Curr Eye Res)
Vol. 13
Issue 5
Pg. 319-24
(May 1994)
ISSN: 0271-3683 [Print] England |
PMID | 8055694
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Allergens
- Ophthalmic Solutions
- Pheniramine
- Naphazoline
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Topics |
- Adult
- Allergens
- Conjunctivitis, Allergic
(drug therapy)
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Humans
- Male
- Middle Aged
- Models, Biological
- Naphazoline
(administration & dosage, therapeutic use)
- Ophthalmic Solutions
- Pheniramine
(administration & dosage, therapeutic use)
- Pollen
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