Early blastic transformation of a myeloproliferative disorder with t(8;21) and progressive aberrations of chromosome 8.

Abstract

We describe a case of a patient affected by a chronic myeloproliferative disorder with t(8;21)(q22;q22) and trisomy 8 at diagnosis. At the time of blastic metamorphosis, 2 months later, trisomy 8 metaphases were significantly reduced, while a predominance of t(8;21) was present. Finally, in the phase of leukemic regrowth following chemotherapy administration, monosomy 8 associated with der(21)t(8;21) was the predominant cytogenetic abnormality.

• Authors: A Fasanaro, G Paone, I Silvestri, V Marottoli, R Cimino, F Ferrara
• Journal: Cancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 75 Issue 2 Pg. 106-10 (Jul 15 1994) ISSN: 0165-4608 [Print] United States
• PMID: 8055472 (Publication Type: Case Reports, Journal Article)

Topics

• Chromosome Aberrations
• Chromosomes, Human, Pair 21
• Chromosomes, Human, Pair 8
• Female
• Humans
• Karyotyping
• Leukemia, Myeloid (genetics)
• Leukemia, Myeloid, Acute (genetics)
• Monosomy
• Translocation, Genetic
• Trisomy