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Predicting oliguria following indomethacin for treatment of patent ductus arteriosus.

Abstract
Fifty-two consecutive infants who received intravenous indomethacin, 0.2 mg/kg, were reviewed to determine factors associated with the occurrence of oliguria. Serum creatinine and concentration prior to indomethacin did not predict the occurrence of oliguria. A mean urine output of less than 4.5 mL/kg/hr prior to the administration of indomethacin was the only factor that we determined to be associated with a significant risk of oliguria. Two infants developed symptomatic oliguria and both had a pre-indomethacin urine output less than 1.5 mL/kg/hr.
AuthorsK J Barrington, M Fox
JournalAmerican journal of perinatology (Am J Perinatol) Vol. 11 Issue 3 Pg. 220-2 (May 1994) ISSN: 0735-1631 [Print] United States
PMID8048989 (Publication Type: Journal Article)
Chemical References
  • Creatinine
  • Indomethacin
Topics
  • Creatinine (blood)
  • Ductus Arteriosus, Patent (drug therapy)
  • Humans
  • Indomethacin (adverse effects)
  • Infant, Newborn
  • Infant, Premature, Diseases (drug therapy)
  • Oliguria (chemically induced)
  • Prognosis

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