Urinary MHPG and clinical symptoms in patients with unipolar depression.

Abstract

The relationship between levels of urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) and symptom scores on the Hamilton Rating Scale for Depression was examined in 31 patients with unipolar depression. Patients with either low MHPG or high MHPG showed significant sleep disturbance in the form of early morning awakening. Patients with mid-range or high MHPG showed decreased work and activities. Endogenomorphy factor scores represented a blend of these findings.

• Authors: J A Samson, S M Mirin, M Griffin, D Borrelli, J J Schildkraut
• Journal: Psychiatry research (Psychiatry Res) Vol. 51 Issue 2 Pg. 157-65 (Feb 1994) ISSN: 0165-1781 [Print] Ireland
• PMID: 8022950 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Triiodothyronine
• Methoxyhydroxyphenylglycol
• Dexamethasone
• Thyrotropin
• Thyroxine
• Hydrocortisone

Topics

• Adult
• Body Weight
• Cognition Disorders (complications, diagnosis, urine)
• Depressive Disorder (complications, diagnosis, urine)
• Dexamethasone
• Female
• Humans
• Hydrocortisone (blood)
• Male
• Methoxyhydroxyphenylglycol (urine)
• Middle Aged
• Psychiatric Status Rating Scales
• Psychomotor Disorders (complications, diagnosis, urine)
• Sleep Wake Disorders (complications, diagnosis, urine)
• Thyrotropin (blood)
• Thyroxine (blood)
• Triiodothyronine (blood)