In this study, it was investigated whether prostate
tumor biological parameters correlate with metabolic profiles. 1H and 31P magnetic resonance spectra were acquired from
perchloric acid extracts of seven Dunning R-3327 prostate
tumor sublines. Several metabolic ratios, for example,
phosphocholine/total
phosphate, choline/total
creatine, and
inositol/total
creatine, did not correlate specifically with one
biological characteristics but, based on each of these ratios, the well-differentiated, nonmetastatic, and
hormone-dependent sublines could be discriminated from the poorly differentiated or anaplastic, metastatic, and
hormone-independent sublines. The
glycerophosphoethanolamine/total
phosphate, glycerophosphocholine/total
phosphate, and
phosphocreatine/total
phosphate ratios correlated with differentiation grade, and the differences in glycerophosphorylglycerol/total
phosphate ratio between metastatic and nonmetastatic sublines was highly significant. No correlation for hormonal sensitivity with any of the metabolites measured could be found, neither by 31P nor by 1H MRS.