Abstract |
The proteins beta-thromboglobulin, platelet factor 4 and thrombospondin are stored in platelet alpha-granules and released from the platelet by the release reaction. The assays of these proteins were studied in patients with type I diabetes mellitus ( n = 30) and a healthy control group (n = 15). Platelet factor 4 and beta-thromboglobulin levels were not significantly different in both groups but thrombospondin concentrations in diabetic patients were significantly higher than those of the control group (136.6 +/- 14.2 ng/ml vs 91.2 +/- 14.3 ng/ml, P < 0.05). When the diabetic patients were divided into those with or without complications, the diabetic patients with complications (n = 11) had significantly elevated plasma thrombospondin concentrations compared with the control group (150.4 +/- 23.7 ng/ml vs 91.2 +/- 14.3 ng/ml, P < 0.05), while thrombospondin concentrations in the control group were not statistically different from the diabetic patients without complications. Plasma beta-thromboglobulin and platelet factor 4 levels were not significantly different between the diabetic and the control group. It is suggested that thrombospondin may be a convenient marker of in vivo platelet release reaction.
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Authors | M Bayraktar, S Dündar, S Kirazli, F Teletar |
Journal | The Journal of international medical research
(J Int Med Res)
1994 Mar-Apr
Vol. 22
Issue 2
Pg. 90-4
ISSN: 0300-0605 [Print] England |
PMID | 8020643
(Publication Type: Journal Article)
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Chemical References |
- Membrane Glycoproteins
- Thrombospondins
- beta-Thromboglobulin
- Platelet Factor 4
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Topics |
- Adult
- Diabetes Mellitus, Type 1
(blood, complications)
- Humans
- Membrane Glycoproteins
(blood)
- Platelet Factor 4
(analysis)
- Thrombospondins
- beta-Thromboglobulin
(analysis)
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