Plasma lipids and lipoprotein-cholesterol distribution in nephrotic syndrome patients during short term high dose steroid treatment.

Abstract

Plasma lipids and lipoprotein-cholesterol profiles were studies in 11 consecutive patients (eight females and three males) with the nephrotic syndrome (NS) during a short term treatment with high dose prednisolone. A significant fall from the high mean pre-treatment levels of total cholesterol and LDL-cholesterol was demonstrated at four, eight and 12 weeks of treatment (p < 0.005) while the fall in the mean triglyceride level only became significant at eight weeks (p < 0.01). The mean HDL-cholesterol level did not change significantly throughout, although there was a significant rise in the mean HDL-cholesterol total cholesterol ratio at four weeks (p = 0.01) and at both eight and 12 weeks (p < 0.005). The study has demonstrated a significant improvement in the lipids and lipoprotein-cholesterol profile of patients with the nephrotic syndrome during a shortterm high dose steroid treatment.

• Authors: A Arije, R T Erasmus, S A Anjorin
• Journal: The Central African journal of medicine (Cent Afr J Med) Vol. 39 Issue 10 Pg. 211-5 (Oct 1993) ISSN: 0008-9176 [Print] Zimbabwe
• PMID: 8020077 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholesterol, HDL
• Cholesterol, LDL
• Serum Albumin
• Triglycerides
• Cholesterol
• Prednisolone

Topics

• Adolescent
• Adult
• Aged
• Biopsy
• Child
• Cholesterol (blood)
• Cholesterol, HDL (blood, drug effects)
• Cholesterol, LDL (blood, drug effects)
• Female
• Humans
• Male
• Middle Aged
• Nephrotic Syndrome (blood, drug therapy, pathology)
• Prednisolone (pharmacology, therapeutic use)
• Serum Albumin (analysis, drug effects)
• Time Factors
• Triglycerides (blood)