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Use of levamisole in maintaining remission in steroid-sensitive nephrotic syndrome in children.

Abstract
A randomized, controlled trial was conducted in a pediatric unit in a teaching hospital in India to assess the efficacy of levamisole in maintaining remission in children with steroid-sensitive nephrotic syndrome. Sixty-one children with steroid-sensitive nephrotic syndrome, who had achieved remission with corticosteroids, were allocated to a treatment group (33 patients) receiving levamisole (2-3 mg/kg/day) twice a week for 12 months or to a control group (28 patients) receiving no treatment. The main outcome measure was duration of remission. Thirty months later, in the levamisole group, 21 of 33 patients were in remission as against 12 of 28 patients in the control group (chi 2 = 2.54, p = 0.11, NS). The median duration of remission maintenance was 12 months in the levamisole group as compared with 10.5 months in the control group. On survival analysis, the difference in duration of remission maintenance between the two groups was not significant (p = 0.10), though there was a trend in favor of the treatment group. On stratified survival analysis, multiple relapsers in the levamisole group had longer remission maintenance than the control group though this did not reach statistical significance (p = 0.08). The clinically significant trend towards increased duration of remission maintenance in steroid-sensitive nephrotic syndrome observed with levamisole therapy, especially in patients with multiple relapses, may require a larger study with a longer follow-up for definitive confirmation.
AuthorsU Dayal, A K Dayal, J C Shastry, P Raghupathy
JournalNephron (Nephron) Vol. 66 Issue 4 Pg. 408-12 ( 1994) ISSN: 1660-8151 [Print] Switzerland
PMID8015643 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Adrenal Cortex Hormones
  • Levamisole
Topics
  • Adrenal Cortex Hormones (therapeutic use)
  • Child
  • Child, Preschool
  • Drug Resistance
  • Female
  • Humans
  • Levamisole (therapeutic use)
  • Male
  • Nephrotic Syndrome (drug therapy)
  • Recurrence

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