High-dose fluconazole for treatment of cryptococcal disease in patients with human immunodeficiency virus infection. The California Collaborative Treatment Group.

Eight patients (6, cryptococcal meningitis; 2, high-titer cryptococcal antigenemia) were treated with 800 mg/day fluconazole to assess the safety and efficacy of high-dose fluconazole as primary therapy. Five patients with meningitis had resolution of clinical symptoms and all 6 had negative cerebrospinal fluid (CSF) cultures by day 82 (median, 21 days). One meningitis patient developed neurologic deterioration and was switched to amphotericin B at day 18, but CSF culture was negative on day 15 of fluconazole therapy. In 2 patients with cryptococcal antigenemia, clinical symptoms resolved and serum antigen titers declined rapidly; they did not progress to meningitis. Therapy was well tolerated, with mainly gastrointestinal side effects. Four patients had mild increases in liver enzymes; another had a threefold increase in alkaline phosphatase. Mean steady-state serum level of fluconazole was 45 +/- 15 micrograms/mL, and paired CSF and serum levels were 40 +/- 14 and 49 +/- 14 micrograms/mL, respectively. High-dose fluconazole appears safe and effective for cryptococcal disease in AIDS patients.
AuthorsR H Haubrich, D Haghighat, S A Bozzette, J Tilles, J A McCutchan
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 170 Issue 1 Pg. 238-42 (Jul 1994) ISSN: 0022-1899 [Print] UNITED STATES
PMID8014509 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Fluconazole
  • AIDS-Related Opportunistic Infections (drug therapy)
  • Cryptococcosis (complications, drug therapy)
  • Fluconazole (administration & dosage, therapeutic use)
  • Humans

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