Abstract | OBJECTIVE: To assess the possible etiological role of hyperprolactinemia in oligospermic African males. DESIGN: Prospective. SETTING: University teaching hospital. PATIENTS AND METHODS: Of the 52 infertile males studied, 23 had oligospermia, 11 were hyperprolactinemic, while 7 had both oligospermia and hyperprolactinemia. Mean serum testosterone concentration was lower in oligospermic than normospermic patients (3.6 +/- 1.9 ng/mL vs. 6.3 +/- 2.8 ng/mL; P < .05), and in hyperprolactinemic than normoprolactinemic patients (2.8 +/- 1.5 ng/mL vs. 5.7 +/- 2.8 ng/mL; P < .05). The patients with both oligospermia and hyperprolactinemia had the lowest mean serum testosterone (2.2 +/- 0.7 ng/mL) concentration. Oral bromocriptine was given to the seven hyperprolactinemic, oligospermic patients for 9-12 weeks. RESULTS: Serum prolactin was reduced to normal in all and increased sperm count to normal in 4/7. The wives of two of the responders became pregnant. CONCLUSIONS: The serum concentration of prolactin should be estimated in all oligospermic patients who exhibit no obvious cause of the oligospermia. Those found to be hyperprolactinemic should be given bromocriptine.
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Authors | O Modebe |
Journal | International journal of fertility and menopausal studies
(Int J Fertil Menopausal Stud)
1994 Mar-Apr
Vol. 39
Issue 2
Pg. 95-9
ISSN: 1069-3130 [Print] United States |
PMID | 8012447
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Bromocriptine
- Testosterone
- Prolactin
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Topics |
- Adult
- Bromocriptine
(therapeutic use)
- Humans
- Hyperprolactinemia
(blood, complications, drug therapy)
- Male
- Middle Aged
- Nigeria
- Oligospermia
(blood, complications, drug therapy)
- Prolactin
(blood)
- Prospective Studies
- Sperm Count
(drug effects)
- Testosterone
(blood)
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