[Rationale for the use of bile salts after cholecystectomy: results of a controlled clinical study using tauroursodeoxycholic acid (TUDCA)].

Abstract

Cholecystectomy causes alterations in bile composition. In particular it rises the proportion of highly detergent bile acids with the possible consequence of the manifestation of dyspepsia in a high percentage of patients: this is the well-known post-cholecystectomy syndrome. In this clinical trial we studied the activity and safety of tauroursodeoxycholic acid--TUDCA--(500 mg/die) in the prevention of dyspepsia in cholecystectomized patients, in comparison with no treated group. We enrolled 203 patients (101 TUDCA--group A--and 102 control-group B). The two groups were comparable for age (47.1 years in group A and 50.7 years in group B), sex (m/f: 28/73 and 37/65 in the two groups) and for other characteristics connected to surgical procedures. After operation all patients suffered from dyspepsia symptoms. In patients treated with TUDCA we registered a prompt regression in severity of symptoms when compared with no treated group: in fact we noted a significant difference only at the first control planned after one month from operation. No difference were registered at the other controls (two and three months after operation). Two patients in A and 3 in group B manifested adverse events. In conclusion, the treatment with TUDCA, a new hydrophilic bile acid, seems to contribute to the improvement of clinical course in cholecystectomized patients.

• Authors: E Croce, M Golia, M Trignano, G Occhioni, J Pisano, R La Rocca, A Capomagi, A De Sanctis, M Morino, M Fornari
• Journal: Annali italiani di chirurgia (Ann Ital Chir) 1993 Sep-Oct Vol. 64 Issue 5 Pg. 533-7 ISSN: 0003-469X [Print] Italy
• Vernacular Title: Razionale all'utilizzo dei sali biliari nel paziente colecistectomizzato: risultati di uno studio clinico controllato con l'impiego dell'acido tauroursodesossicolico (TUDCA).
• PMID: 8010582 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Taurochenodeoxycholic Acid
• ursodoxicoltaurine

Topics

• Adult
• Aged
• Aged, 80 and over
• Cholecystectomy (adverse effects)
• Dyspepsia (etiology, prevention & control)
• Female
• Follow-Up Studies
• Humans
• Isomerism
• Male
• Middle Aged
• Postoperative Complications (prevention & control)
• Taurochenodeoxycholic Acid (therapeutic use)