Abstract | PURPOSE: METHODS AND MATERIALS: Human lung cancer xenografts in the right hind legs of KSN mice (10 weeks old) were locally irradiated with 20 Gy of X ray. Adrenochrome monoaminogluanidine methanesulfonate (AMM) (10 mg/kg/day) and/or cytochrome C (CCC) (5 mg/kg/day) were given intraperitoneally immediately before or after RT, followed by daily administration for 4 days. Natural killer activities of host splenocytes were also tested with the standard 51Cr releasing assay with YAC-1 cells as target cells. In a clinical study, 65 patients with lung cancer were treated with more than 50 Gy of RT with or without combination with AMM+CCC, OK-432 or AMM+CCC+ OK-432. Before and after RT, lymphocyte subsets in the peripheral blood were examined with dichromatic analysis using an Ortho Spectrum IIIFCM system and fluorescent MABs. In this study, the change in the absolute number of each subset was investigated. RESULTS: CONCLUSION:
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Authors | S Nakatsugawa, T Sugahara |
Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 29
Issue 3
Pg. 635-8
(Jun 15 1994)
ISSN: 0360-3016 [Print] United States |
PMID | 8005829
(Publication Type: Journal Article)
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Chemical References |
- Cytochrome c Group
- Radiation-Protective Agents
- Radiation-Sensitizing Agents
- S-Adchnon
- Adrenochrome
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Topics |
- Adrenochrome
(analogs & derivatives, pharmacology)
- Animals
- Cytochrome c Group
(pharmacology)
- Humans
- Killer Cells, Natural
(drug effects, radiation effects)
- Lung Neoplasms
(radiotherapy)
- Male
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Radiation-Protective Agents
(pharmacology)
- Radiation-Sensitizing Agents
(pharmacology)
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