[Padma-28, a herbal preparation, increases walking distance in patients with intermittent claudication].

Abstract

Thirty-six patients with stable intermittent claudication were randomized in a doubleblind study either to treatment with two tablets of Padma-28 twice daily (containing 340 mg dried herbal mixture composed according to an ancient lamaistic prescription) or placebo for four months. Effect of treatment was quantified by measurements of systemic and peripheral systolic blood pressures, and pain-free and maximal walking distances on a tread-mill. The actively treated group attained a significant increase in pain-free walking distance from 115 m (72-218) to 227 m (73- >1000, p < 0.05). The placebo group did not show significant changes in either pain-free or maximal walking distance. Significant changes in systemic or peripheral blood pressures could not be demonstrated in any of the groups. In conclusion, our study has shown that treatment with Padma-28 over a four month period significantly increases the walking distance in patients with stable intermittent claudication of long duration.

• Authors: H Drabaek, J Mehlsen, J R Petersen, H Himmelstrup, K F Hansen
• Journal: Ugeskrift for laeger (Ugeskr Laeger) Vol. 156 Issue 42 Pg. 6207-9 (Oct 17 1994) ISSN: 0041-5782 [Print] Denmark
• Vernacular Title: Padma-28, et urtepraeparat, øger gangdistancen hos patienter med claudicatio intermittens.
• PMID: 7998359 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Drugs, Chinese Herbal
• Placebos

Topics

• Aged
• Double-Blind Method
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Humans
• Intermittent Claudication (drug therapy, physiopathology)
• Male
• Middle Aged
• Placebos
• Walking