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Bone marrow transplantation in patients with acute leukemia.

Abstract
At least three factors may be responsible for leukemic relapse in patients receiving ABMT: (a) minimal residual disease; (b) leukemic cells reinfused with the graft; and (c) the lack of a graft-versus leukemia effect. Techniques for pharmacological marrow decontamination, clinical result obtained with ABMT and the efficacy of ABMT with mafosfamide purged marrow in patients with acute myelogenous leukemia are reviewed.
AuthorsC Caramatti, L Mangoni, C Carlo-Stella, V Rizzoli
JournalActa bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma (Acta Biomed Ateneo Parmense) Vol. 64 Issue 5-6 Pg. 213-20 ( 1993) Italy
PMID7992558 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Adjuvants, Immunologic
  • Antineoplastic Agents
  • mafosfamide
  • Cyclophosphamide
Topics
  • Adjuvants, Immunologic (pharmacology)
  • Antineoplastic Agents (pharmacology)
  • Bone Marrow (drug effects)
  • Bone Marrow Transplantation (methods)
  • Cyclophosphamide (analogs & derivatives, pharmacology)
  • Humans
  • Leukemia, Myeloid, Acute (therapy)
  • Recurrence
  • Time Factors
  • Transplantation, Autologous

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