[Therapy by neutron capture of ocular melanoma: dosimetry and microdosimetry].

Abstract

Neutron capture therapy (NCT) aims at destroying cancerous cells with the alpha and 7Li particles produced by the neutron capture reaction on 10B. This note reports on the study of the boron distribution in tissues on an animal model (nude mice) xenografted with a human ocular melanoma after an i.p.injection of 2g/kg of 10B-BPA and in cells cultured in the presence of 530 mumol/l of 10B-BPA. A concentration of 64 ppm of 10B in the active part of the tumour with a ratio of concentrations versus the skin of 3.7 are observed. Investigations on cells reveal the presence of boron in the cytoplasm. The biological, dosimetric and microdosimetric consequences of these findings are discussed.

• Authors: J P Pignol, J C Abbe, O Lefebvre, A Stampfler, G Methlin, J Sahel
• Journal: Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie (C R Acad Sci III) Vol. 317 Issue 6 Pg. 543-8 (Jun 1994) ISSN: 0764-4469 [Print] France
• Vernacular Title: Thérapie par capture de neutrons des mélanomes oculaires: approches dosimétrique et microdosimétrique.
• PMID: 7987706 (Publication Type: English Abstract, Journal Article)

Topics

• Animals
• Boron Neutron Capture Therapy
• Eye Neoplasms (pathology, radiotherapy)
• Film Dosimetry (methods)
• Melanoma, Experimental (pathology, radiotherapy)
• Mice
• Mice, Nude
• Tumor Cells, Cultured