[Interaction of interferon with retinoic acid].

Abstract

Lippman and coworkers recently reported striking response rates achieved in patients with cervical cancer using a combined treatment with 13-cis-retinoic acid and interferon-alpha. In vitro studies demonstrated a synergistic amplification of proliferation inhibition by retinoids and interferon in malignant cells. Comparing all-trans- with 9-cis-retinoic acid, the latter was more effective in inhibiting tumor cell growth and in inducing synergism with interferon-gamma. Combination of retinoic acid with interferon-gamma increased the down-regulation of specific binding sites of interferon-gamma. Expression of MHC class II antigens induced by interferon-gamma was not further enhanced by retinoic acid. These results indicate that interferon seems to modulate the retinoic acid system.

• Authors: M Widschwendter, G Daxenbichler, C Marth, O Dapunt
• Journal: Gynakologisch-geburtshilfliche Rundschau (Gynakol Geburtshilfliche Rundsch) Vol. 34 Issue 3 Pg. 168-70 ( 1994) ISSN: 1018-8843 [Print] Switzerland
• Vernacular Title: Interaktion von Interferon mit Vitamin-A-Säure.
• PMID: 7987085 (Publication Type: English Abstract, Journal Article)

Chemical References

• Tretinoin
• Interferon-gamma

Topics

• Breast Neoplasms (pathology)
• Cell Division (drug effects)
• Cell Line
• Cell Survival (drug effects)
• Drug Synergism
• Female
• Humans
• Interferon-gamma (pharmacology)
• Tretinoin (pharmacology)
• Tumor Cells, Cultured (drug effects, pathology)