HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Anti-ischemia activity of HU-211, a non-psychotropic synthetic cannabinoid.

Abstract
The novel tricyclic-terpenoid type cannabinoid, HU-211, was tested in gerbils and rats for protection against the effects of cerebral ischemia. Our transient ischemic models in gerbils and rats are based on the protection afforded against the lethal effects of global ischemia. HU-211 gave over 30% protection, by i.v. administration. The optimal dose ranges of HU-211 were between 5 and 10 mg/kg i.v. In gerbils we used a transient ischemia model induced by occlusion (10 min) of the bilateral common carotid arteries (BCCA). HU-211, 8 mg/kg i.v., gave a significantly (p < or = 0.05) better in vivo performed than a control group over three days following ischemia. Histology performed in gerbil model also resulted in significantly (p < 0.001) diminished degeneration area of CA1 in the hippocampus after treatment of HU-211. In the rat model, after four vessel occlusion (4VO) (20 min), HU-211 treatment significantly (p < 0.01) improved neurobehavior scoring. These results show that the new synthetic cannabinoid can protect against hippocampal neuron damage due to selective brain injury induced by cerebral global ischemia in gerbils or rats.
AuthorsM Vered, A Bar-Joseph, L Belayev, Y Berkovich, A Biegon
JournalActa neurochirurgica. Supplementum (Acta Neurochir Suppl (Wien)) Vol. 60 Pg. 335-7 ( 1994) Austria
PMID7976583 (Publication Type: Journal Article)
Chemical References
  • Receptors, N-Methyl-D-Aspartate
  • Dronabinol
  • HU 211
Topics
  • Animals
  • Brain (drug effects, pathology)
  • Brain Edema (pathology)
  • Brain Ischemia (pathology)
  • Dronabinol (analogs & derivatives, pharmacology)
  • Gerbillinae
  • Hippocampus (drug effects, pathology)
  • Injections, Intravenous
  • Ischemic Attack, Transient (pathology)
  • Male
  • Nerve Degeneration (drug effects)
  • Neurologic Examination (drug effects)
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, N-Methyl-D-Aspartate (antagonists & inhibitors)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: