Abstract |
The elucidation of the clinical features of human T-lymphotropic virus type I (HTLV-I) associated uveitis (HAU) was advanced by the results of a multicenter study performed by the collaboration of university hospitals throughout Kyushu and Okinawa and two institutions in the Tokyo-Yokohama metropolitan areas of Japan. A total of 426 cases of endogenous uveitis were registered during the five-month study period between September 1992 and January 1993. The etiology and clinical entity remained unknown for about half of these cases. A series of 50 cases of HTLV-I seropositive, entity-undefined uveitis were suspected to be HAU, and analyses of these cases provided the following clinical features of this recently defined uveitis entity. 1) middle-aged adult of either sex develops acute, inflammatory uveal disease and presents with visual haze or floaters, or both; 2) active disease consists of granulomatous or nongranulomatous reactions accompanied by vitreous opacities and retinal vasculitis with rare retinochoroidal exudative changes; 3) the disease resolves with response to corticosteroids, although leaving sequelae in occasional cases; 4) the disease affects one or both eyes, and up to half of cases show recurrent disease within years; 5) the visual outcome is usually favorable; 6) the disease occurs as an isolated disorder, but may sometimes be complicated by HTLV-I associated myelopathy. Hyperthyroidism is also associated in occasional cases; 7) the titer of serum HTLV-I antibodies is significantly high compared with that of HTLV-I carriers, suggesting an immune mechanism as the pathogenesis of HAU.
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Authors | N Ohba, K Nakao, Y Isashiki, T Kaminagayoshi, S Sonoda, S Yashiki, M Osame |
Journal | Japanese journal of ophthalmology
(Jpn J Ophthalmol)
Vol. 38
Issue 2
Pg. 168-74
( 1994)
ISSN: 0021-5155 [Print] Japan |
PMID | 7967208
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glucocorticoids
- HTLV-I Antibodies
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Topics |
- Adolescent
- Adult
- Aged
- Case-Control Studies
- Child
- Eye Infections, Viral
(diagnosis, drug therapy, physiopathology)
- Female
- Glucocorticoids
(therapeutic use)
- HTLV-I Antibodies
(analysis)
- HTLV-I Infections
(diagnosis, drug therapy, physiopathology)
- Humans
- Male
- Middle Aged
- Uveitis
(diagnosis, drug therapy, physiopathology, virology)
- Vision Disorders
(diagnosis)
- Visual Acuity
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