Abstract |
Immunohistochemical study on localization of apo E in normal and abnormal adrenal tissues was performed using polyclonal anti-human apo E antibodies. In normal adrenal glands, the cortex showed intense staining, in particular, in the zona fasciculata and the zona reticularis, while the medulla showed weak staining. In a case of adrenal hyperplasia, apo E immunoreactivity was equivalent to that in the normal cortex. In adenomas (primary aldosteronism, n = 7; Cushing's syndrome, n = 2; others, n = 2), apo E was stained normally or to some extent weakly in comparison with the normal cortex. Adrenocortical carcinoma showed only faint staining. The results indicate that apo E may relate to the functional activity of adrenal cortex, and suggest that immunohistochemical study for apo E may help to distinguish the malignancy from benign adrenal neoplasms.
|
Authors | Y Umemori, H Chiba, H Takahashi, H Matui, Y Tokusashi, N Miyokawa |
Journal | Rinsho byori. The Japanese journal of clinical pathology
(Rinsho Byori)
Vol. 42
Issue 9
Pg. 977-80
(Sep 1994)
ISSN: 0047-1860 [Print] Japan |
PMID | 7967124
(Publication Type: English Abstract, Journal Article)
|
Chemical References |
- Apolipoproteins E
- Biomarkers, Tumor
|
Topics |
- Adenocarcinoma
(metabolism)
- Adenoma
(metabolism)
- Adrenal Gland Neoplasms
(metabolism)
- Adrenal Glands
(metabolism)
- Apolipoproteins E
(analysis)
- Biomarkers, Tumor
(analysis)
- Humans
- Immunohistochemistry
- Neoplasm Staging
|