Sera from some patients with antibody-associated paraneoplastic encephalomyelitis/sensory neuronopathy recognize the Ro-52K antigen.

Abstract	Screening a small cell lung cancer cDNA library with serum from a patient with antibody-associated paraneoplastic sensory neuronopathy (Anti-Hu syndrome) resulted in the isolation of a cDNA clone encoding the Ro-52 kD antigen. The Ro-52 kD antigen is one of the major antigens recognized by the sera of patients with Sjögren's syndrome and systemic lupus erythematosus. Further investigation revealed that the sera of only a small percentage (4%) of patients with the Hu syndrome reacted with Ro-52 kD antigen. The cross-reactivity may result from a domain of high homology between Ro-52 kD and HuD antigen. These results emphasize the necessity of using recombinant antigens whenever possible when assaying for assaying for specific antibodies.
Authors	G Manley, E Wong, J Dalmau, K Elkon, J Posner, H Furneaux
Journal	Journal of neuro-oncology (J Neurooncol) Vol. 19 Issue 2 Pg. 105-12 ( 1994) ISSN: 0167-594X [Print] United States
PMID	7964985 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Antibodies Autoantigens DNA, Complementary ELAV Proteins ELAV-Like Protein 4 ELAVL4 protein, human Molecular Probes Nerve Tissue Proteins RNA, Small Cytoplasmic RNA-Binding Proteins RO60 protein, human Recombinant Fusion Proteins Ribonucleoproteins SS-A antigen
Topics	Amino Acid Sequence Antibodies (immunology) Autoantigens (genetics, immunology) Base Sequence Blood (immunology) Cloning, Molecular DNA, Complementary (genetics) ELAV Proteins ELAV-Like Protein 4 Encephalomyelitis (blood) Humans Molecular Probes (genetics) Molecular Sequence Data Molecular Weight Nerve Tissue Proteins Paraneoplastic Syndromes (blood) RNA, Small Cytoplasmic RNA-Binding Proteins (immunology) Recombinant Fusion Proteins (immunology) Ribonucleoproteins (genetics, immunology) Sensation Disorders (blood)

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