Abstract | BACKGROUND:
Keratoacanthoma is a benign epithelial tumor that occurs on the sun-exposed skin of elderly people. Development of KAS on functionally and cosmetically important areas such as the face poses the therapeutic challenge to minimize functional and cosmetic damage. Oral isotretinoin ( Accutane, Roche Laboratories) has been reported to be an effective treatment of multiple as well as solitary keratoacanthomas. CASE REPORT: A 45-year-old man with a large keratoacanthoma on the nasal ala, recurrent after surgical excision, was treated with 1 mg/kg/day (80 mg/day) oral isotretinoin ( Accutane). Cessation of tumor progression was evident within 1 week after initiation of therapy, and tumor regression was evident within 2 weeks. Tumor size diminished rapidly over the ensuing weeks and complete resolution at 12 weeks was confirmed by biopsy. CONCLUSION:
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Authors | W Y Wong, R V Kolbusz, L H Goldberg, A Guana |
Journal | International journal of dermatology
(Int J Dermatol)
Vol. 33
Issue 8
Pg. 579-83
(Aug 1994)
ISSN: 0011-9059 [Print] England |
PMID | 7960358
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Administration, Oral
- Biopsy
- Combined Modality Therapy
- Humans
- Isotretinoin
(administration & dosage, therapeutic use)
- Keratoacanthoma
(drug therapy, pathology, surgery)
- Male
- Middle Aged
- Nose Diseases
(drug therapy, pathology, surgery)
- Recurrence
- Remission Induction
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