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Effect of topical calcipotriol on congenital ichthyoses.

Abstract
We investigated the clinical efficacy of topically applied calcipotriol in six patients with congenital ichthyosis, using a double-blind, bilaterally paired, comparative approach. Unilateral improvement, in favour of the calcipotriol-treated side, was observed in three patients with lamellar ichthyosis. A beneficial response was also observed in a patient with bullous ichthyotic erythroderma of Brocq. No clinical side-effects or laboratory anomalies were observed. This study indicates that calcipotriol constitutes a new and promising approach in alleviating disorders of keratinization characterized by hyperproliferation, other than psoriasis.
AuthorsG P Lucker, P C van de Kerkhof, M R van Dïjk, P M Steijlen
JournalThe British journal of dermatology (Br J Dermatol) Vol. 131 Issue 4 Pg. 546-50 (Oct 1994) ISSN: 0007-0963 [Print] England
PMID7947208 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References
  • Dermatologic Agents
  • Excipients
  • calcipotriene
  • Calcitriol
Topics
  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Calcitriol (administration & dosage, analogs & derivatives)
  • Dermatologic Agents (administration & dosage)
  • Double-Blind Method
  • Excipients (administration & dosage)
  • Female
  • Humans
  • Ichthyosis (drug therapy)
  • Male
  • Middle Aged
  • Prospective Studies
  • Skin (drug effects)

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