Abstract |
We investigated the clinical efficacy of topically applied calcipotriol in six patients with congenital ichthyosis, using a double-blind, bilaterally paired, comparative approach. Unilateral improvement, in favour of the calcipotriol-treated side, was observed in three patients with lamellar ichthyosis. A beneficial response was also observed in a patient with bullous ichthyotic erythroderma of Brocq. No clinical side-effects or laboratory anomalies were observed. This study indicates that calcipotriol constitutes a new and promising approach in alleviating disorders of keratinization characterized by hyperproliferation, other than psoriasis.
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Authors | G P Lucker, P C van de Kerkhof, M R van Dïjk, P M Steijlen |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 131
Issue 4
Pg. 546-50
(Oct 1994)
ISSN: 0007-0963 [Print] England |
PMID | 7947208
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Dermatologic Agents
- Excipients
- calcipotriene
- Calcitriol
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Topics |
- Administration, Cutaneous
- Adolescent
- Adult
- Calcitriol
(administration & dosage, analogs & derivatives)
- Dermatologic Agents
(administration & dosage)
- Double-Blind Method
- Excipients
(administration & dosage)
- Female
- Humans
- Ichthyosis
(drug therapy)
- Male
- Middle Aged
- Prospective Studies
- Skin
(drug effects)
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