Abstract | OBJECTIVE: METHODS: Patients with Barrett's esophagus at least 3 cm long and with specialized columnar epithelium were treated with 60 mg of lansoprazole each morning. Every 6 months, patients had standardized symptomatic, laboratory, and endoscopic assessment. The length of Barrett's esophagus was measured, photo-documented, and biopsied. RESULTS: Twenty-seven patients with Barrett's esophagus have been treated an average of 2.9 yr. Symptoms improved (70%, 19 patients), and erosive esophagitis healed (100%, 13 patients), but there was no significant reduction in the length of Barrett's epithelium (mean length at baseline 5.7 cm, final visit 5.3 cm). However, by the final visit, 20 of 26 patients (77%) had squamous islands: two unchanged in size, six with increased surface area, and 12 newly developed on therapy. Initially, mean fasting gastrin levels rose significantly but then plateaued after 1 month of therapy. Of 10 patients with gastrin levels for 18 months or longer, only one had a level > or = 400 pg/ml. CONCLUSIONS:
Lansoprazole 60 mg for up to 3 yr was safe and effective in controlling symptoms and esophagitis. The impact on the extent of Barrett's esophagus over this time interval was manifested by the extension and development of squamous islands.
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Authors | R E Sampliner |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 89
Issue 10
Pg. 1844-8
(Oct 1994)
ISSN: 0002-9270 [Print] United States |
PMID | 7942680
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Gastrins
- Proton Pump Inhibitors
- Lansoprazole
- Omeprazole
|
Topics |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Adult
- Aged
- Aged, 80 and over
- Barrett Esophagus
(blood, drug therapy, pathology)
- Epithelium
(pathology)
- Esophagus
(pathology)
- Female
- Gastrins
(blood)
- Humans
- Lansoprazole
- Male
- Middle Aged
- Omeprazole
(administration & dosage, analogs & derivatives, therapeutic use)
- Proton Pump Inhibitors
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