[10 days of triple treatment of Helicobacter pylori infection and peptic ulcer. Status after treatment of 4 weeks and of one year].

Abstract

We treated 143 Helicobacter pylori positive ulcer patients (duodenal ulcer 81, gastric ulcer 24, pyloric ulcer nine, previous duodenal ulcer 27, others two) with a ten days regimen of bismuth subnitrate, oxytetracycline and metronidazole. Four weeks after cessation of treatment the 14C-urea breath test showed that the infection was eradicated in 133 out of 140 patients (95%). The ulcer had healed in 129 (97%) of the H. pylori negative patients. Status at one year after treatment showed that 121 (98.4%) of 123 patients who had become H. pylori negative had remained negative. None of the H. pylori negative patients experienced ulcer relapse. The results show that the treatment is effective and that the rate of recurrence of H. pylori during the first year is very low.

• Authors: A Berstad, K Berstad, J G Hatlebakk, I Wilhelmsen, G Nysaeter, C J Bang, T Hausken, L B Nesje, A S Hjartholm, O Hundal
• Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke (Tidsskr Nor Laegeforen) Vol. 114 Issue 21 Pg. 2477-9 (Sep 10 1994) ISSN: 0029-2001 [Print] Norway
• Vernacular Title: Ti dagers trippelkur for Helicobacter pylori-infeksjon og magesår. Status fir uker og ett år etter.
• PMID: 7940447 (Publication Type: Journal Article)

Chemical References

• Metronidazole
• Bismuth
• Oxytetracycline

Topics

• Adult
• Aged
• Bismuth (administration & dosage)
• Drug Therapy, Combination
• Female
• Follow-Up Studies
• Helicobacter Infections (drug therapy)
• Helicobacter pylori (drug effects)
• Humans
• Male
• Metronidazole (administration & dosage)
• Middle Aged
• Oxytetracycline (administration & dosage)
• Peptic Ulcer (drug therapy, microbiology)
• Time Factors