Modification of 2,2',2''-tripyridine-induced tremor in mice by serotonergic agonists and antagonists and benzodiazepines.

Abstract

The administration of 2,2',2''-tripyridine produced generalized tremor, myoclonus, and hindlimb abduction, similar to the "5-hydroxytryptamine (5-HT) syndrome," in mice. Pretreatment with mianserin, cyproheptadine, methysergide, or metergoline ameliorated, whereas 5-hydroxytryptophan (5-HTP), 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), or 8-hydroxy-2-[di-n-propylamino]tetraline hydrobromide (8-OH-DPAT) augmented the 2,2',2''-tripyridine-induced tremor. Furthermore, diazepam and flunitrazepam exhibited a dose-dependent protection against 2,2',2''-tripyridine-induced tremor in mice, but pentobarbital only had a slightly protective effect. The inhibitory effects of diazepam and flunitrazepam on the 2,2',2''-tripyridine-induced tremor were potentiated in mice pretreated with p-chlorophenylalanine (PCPA). These observations suggest a serotonin-mediated action of 2,2',2''-tripyridine in its tremor action and that the benzodiazepine agonist attenuation of the 2,2',2''-tripyridine-induced tremor is probably mediated through the GABAergic inhibition of serotonergic neurons.

• Authors: S Y Lin-Shiau, K S Hsu
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 48 Issue 3 Pg. 665-70 (Jul 1994) ISSN: 0091-3057 [Print] United States
• PMID: 7938120 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Anxiety Agents
• Chelating Agents
• Pyridines
• Serotonin Antagonists
• Serotonin Receptor Agonists
• Benzodiazepines
• 2,2',2''-terpyridine
• Pentobarbital
• Fenclonine

Topics

• Animals
• Anti-Anxiety Agents (pharmacology)
• Behavior, Animal (drug effects)
• Benzodiazepines
• Chelating Agents (administration & dosage, toxicity)
• Fenclonine (pharmacology)
• Injections, Intraperitoneal
• Male
• Mice
• Mice, Inbred ICR
• Pentobarbital (pharmacology)
• Pyridines (administration & dosage, antagonists & inhibitors, toxicity)
• Serotonin Antagonists (pharmacology)
• Serotonin Receptor Agonists (pharmacology)
• Tremor (chemically induced, prevention & control)