Anti-Ro(SSA) antibodies in patients with rheumatoid arthritis--a possible marker for gold induced side effects.

Abstract

OBJECTIVE:

To determine whether anti-Ro antibodies are associated with gold induced side effects.

METHODS:

A retrospective chart review of 208 patients with rheumatoid arthritis (RA) and examination of sera for the presence of anti-Ro antibodies by enzyme linked immunosorbent assay.

RESULTS:

Anti-Ro antibodies were detected in 44 (21%) of our patients with RA and their presence correlated with positive rheumatoid factor, antinuclear antibody, and secondary Sjögren's syndrome. Thirty-three out of 48 patients with gold induced side effects (69%) were anti-Ro positive in contrast to 11 patients (7.5%) with positive antibodies with no side effects (p < 0.001). Mucocutaneous reactions had the only significant correlation (p < 0.01) with the presence of anti-Ro antibodies.

CONCLUSION:

Patients with RA with anti-Ro antibodies are prone to develop mucocutaneous side effects to gold salts.

• Authors: M Tishler, B Golbrut, Y Shoenfeld, M Yaron
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 21 Issue 6 Pg. 1040-2 (Jun 1994) ISSN: 0315-162X [Print] Canada
• PMID: 7932411 (Publication Type: Journal Article)

Chemical References

• Antibodies, Antinuclear
• Biomarkers
• SS-A antibodies
• Gold

Topics

• Antibodies, Antinuclear (analysis)
• Arthritis, Rheumatoid (drug therapy, immunology)
• Biomarkers
• Female
• Gold (adverse effects, therapeutic use)
• Humans
• Male
• Middle Aged
• Retrospective Studies