Cytotoxic constituents of Baccharis gaudichaudiana.

Abstract

Three new labdane diterpenes, gaudichaudols A-C [1-3], a new clerodane diterpenoid, gaudichaudone [4], and the known clerodane, articulin acetate [5] have been isolated from the aerial parts of Baccharis gaudichaudiana, together with the known compounds, apigenin, hispidulin, spathulenol, and ursolic acid. Through the application of 1D- and 2D nmr spectroscopy, the structures of the new diterpenoids [1-4] were, in turn; elucidated as 15,16,18,19-tetrahydroxylabd-5-ene, 15-O-acetyl-16,18,19-trihydroxylabd-5-ene, 16-O-p-trans-coumaroyl-15,18,19-trihydroxylabd-5-ene, and 2 beta-hydroxy-15,16-epoxycleroda-1(10),15,16-trien-18,19-olide++ +. The isolated compounds were evaluated in P-388 lymphocytic leukemia cells as well as a battery of human cancer cell lines. Among the diterpenoids, gaudichaudol C [3], gaudichaudone [4], and articulin acetate [5] exhibited significant cytotoxic activity against certain cancer cells.

• Authors: F Fullas, R A Hussain, H B Chai, J M Pezzuto, D D Soejarto, A D Kinghorn
• Journal: Journal of natural products (J Nat Prod) Vol. 57 Issue 6 Pg. 801-7 (Jun 1994) ISSN: 0163-3864 [Print] United States
• PMID: 7931367 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents, Phytogenic
• Diterpenes

Topics

• Animals
• Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
• Diterpenes (isolation & purification, pharmacology)
• Drug Screening Assays, Antitumor
• Humans
• Mice
• Plants, Medicinal (chemistry)
• South America
• Tumor Cells, Cultured