Cytotoxic constituents of Baccharis gaudichaudiana.

Three new labdane diterpenes, gaudichaudols A-C [1-3], a new clerodane diterpenoid, gaudichaudone [4], and the known clerodane, articulin acetate [5] have been isolated from the aerial parts of Baccharis gaudichaudiana, together with the known compounds, apigenin, hispidulin, spathulenol, and ursolic acid. Through the application of 1D- and 2D nmr spectroscopy, the structures of the new diterpenoids [1-4] were, in turn; elucidated as 15,16,18,19-tetrahydroxylabd-5-ene, 15-O-acetyl-16,18,19-trihydroxylabd-5-ene, 16-O-p-trans-coumaroyl-15,18,19-trihydroxylabd-5-ene, and 2 beta-hydroxy-15,16-epoxycleroda-1(10),15,16-trien-18,19-olide++ +. The isolated compounds were evaluated in P-388 lymphocytic leukemia cells as well as a battery of human cancer cell lines. Among the diterpenoids, gaudichaudol C [3], gaudichaudone [4], and articulin acetate [5] exhibited significant cytotoxic activity against certain cancer cells.
AuthorsF Fullas, R A Hussain, H B Chai, J M Pezzuto, D D Soejarto, A D Kinghorn
JournalJournal of natural products (J Nat Prod) Vol. 57 Issue 6 Pg. 801-7 (Jun 1994) ISSN: 0163-3864 [Print] UNITED STATES
PMID7931367 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • Animals
  • Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
  • Diterpenes (isolation & purification, pharmacology)
  • Drug Screening Assays, Antitumor
  • Humans
  • Mice
  • Plants, Medicinal (chemistry)
  • South America
  • Tumor Cells, Cultured

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: