Abstract | OBJECTIVES: BACKGROUND: METHODS: RESULTS:
Gamma-glutamylcysteine ethyl ester effectively reduced infarct size in a dose-dependent manner (mean +/- SEM 26.4 +/- 3.5% in the low dose group [3 mg/kg, n = 10] and 19.0 +/- 3.4% in the high dose group [10 mg/kg, n = 10]; each p < 0.05 vs. the value in the control group [40.6 +/- 4.8%, n = 10]). There were no differences between the control and treated groups in hemodynamic variables or regional myocardial blood flow either during the ischemic period or after reperfusion. The reduced glutathione content of ischemic myocardium in the control group (0.62 +/- 0.11 mumol/g, p < 0.01) was significantly lower than that in nonischemic myocardium (1.46 +/- 0.07 mumol/g), and it was preserved by treatment in a dose-dependent manner (3 mg/kg, 0.83 +/- 0.06 mumol/g; 10 mg/kg, 0.92 +/- 0.14 mumol/g; each p < 0.05 vs. control level). There were no differences in oxidized glutathione content between nonischemic and ischemic myocardium or among the three groups. CONCLUSIONS:
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Authors | S Hoshida, T Kuzuya, N Yamashita, M Nishida, S Kitahara, M Hori, T Kamada, M Tada |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 24
Issue 5
Pg. 1391-7
(Nov 01 1994)
ISSN: 0735-1097 [Print] United States |
PMID | 7930265
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dipeptides
- N-gamma-glutamylcysteine ethyl ester
- Glutathione Peroxidase
- Glutathione Reductase
- Glutathione
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Topics |
- Animals
- Coronary Circulation
(physiology)
- Dipeptides
(administration & dosage, therapeutic use)
- Dogs
- Female
- Glutathione
(metabolism)
- Glutathione Peroxidase
(metabolism)
- Glutathione Reductase
(metabolism)
- Injections, Intravenous
- Male
- Myocardial Infarction
(metabolism, prevention & control)
- Myocardial Reperfusion
- Myocardial Reperfusion Injury
(metabolism, prevention & control)
- Myocardium
(metabolism)
- Oxidation-Reduction
- Time Factors
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