Effect of 13-Nle-motilin in postoperative ileus patients: a double-blind trial.

Abstract

In this study, the effect of 13-norleucine motilin (13-Nle-M) on post-cholecystectomy ileus was assessed in 6 female patients. 13-Nle-M given by continuous i.v. infusion (0.4 mug/kg-h) on the second and third day following surgery did not influence the manifestation and duration of intestinal paralysis in comparison to 6 control patients treated with 0.9% saline. Bowel sounds, however, were more pronounced in the 13-Nle-M-group. Blood pressure and pulse rate were not influenced by the polypeptide, and no other side effects were seen, either.

• Authors: H Ruppin, D Kirndörfer, S Domschke, W Domschke, K Schwemmle, E Wünsch, L Demling
• Journal: Scandinavian journal of gastroenterology. Supplement (Scand J Gastroenterol Suppl) Vol. 39 Pg. 89-92 ( 1976) ISSN: 0085-5928 [Print] England
• PMID: 792985 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Gastrointestinal Hormones
• Placebos
• Motilin

Topics

• Adult
• Aged
• Cholecystectomy
• Clinical Trials as Topic
• Drug Evaluation
• Female
• Gastrointestinal Hormones (therapeutic use)
• Humans
• Intestinal Obstruction (drug therapy)
• Intestinal Pseudo-Obstruction (drug therapy, etiology)
• Middle Aged
• Motilin (analogs & derivatives, therapeutic use)
• Placebos
• Postoperative Complications (drug therapy)