Abstract |
We studied a 58-year-old black woman from Barbados who simultaneously developed myelopathy and lymphoma with human T-lymphotropic virus type I ( HTLV-I) antibodies in serum and cerebrospinal fluid and died 3 years after onset. Neuropathological examination showed typical tropical spastic paraparesis (TSP). The polymerase chain reaction (PCR) demonstrated defective proviral genome retaining the HTLV-I pX and env regions in thoracic spinal cord, the level most severely affected. Defective HTLV-I in the nervous system retaining the pX region may be relevant to pathogenesis because circulating CD8+ cytotoxic lymphocytes specific for HTLV-I pX occur in HTLV-I myelopathy. This patient's lymph node biopsy specimen was consistent with Hodgkin's disease (HD), nodular sclerosis subtype, of B-cell origin. The PCR in the paraffin-embedded lymph node involved by HD failed to amplify HTLV-I proviral sequences. Complete HTLV-I proviral amplification was obtained in paraffin-embedded lymph nodes form positive controls ( adult T-cell leukemia). To our knowledge the association of TSP and HD has not been reported previously. Despite claims that HD may be associated with HTLV-I, we demonstrated absence of HTLV-I-infected T cells in the lymphoid infiltrate of HD in this case, positive HTLV-I serology notwithstanding.
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Authors | L Navarro-Román, D O Corbin, D Katz, D P Callender, P R Prussia, S Garriques, H S Fraser, E S Jaffe, G C Román |
Journal | Human pathology
(Hum Pathol)
Vol. 25
Issue 10
Pg. 1101-6
(Oct 1994)
ISSN: 0046-8177 [Print] United States |
PMID | 7927317
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- DNA, Viral
(genetics, isolation & purification)
- Female
- Hodgkin Disease
(complications, pathology, virology)
- Human T-lymphotropic virus 1
(genetics, isolation & purification)
- Humans
- Lymph Nodes
(pathology)
- Middle Aged
- Paraparesis, Tropical Spastic
(complications, pathology, virology)
- Spinal Cord
(pathology, virology)
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