Abstract |
We report the case of a 28-year old asthmatic female patient, who developed an acute heart failure beginning with diarrhea, fever, and dyspnea 5 weeks after delivery. After improvement of all vital functions and dismissal from hospital care unit a marked blood hypereosinophilia, left ventricular congestive heart failure, pericardium effusion and fever up to 40 degrees C followed. Endomycardial, bone marrow and skeletal muscle biopsies and the pericardial fluid showed a marked eosinophilic infiltration or polymyositis, respectively, which could be treated successfully with steroids and azathioprin. During steroid medication cytomegalovirus-associated myocarditis developed and was diagnosed by in situ hybridization. CMV hyperimmunoglobulin treatment ( Cytotect, Biotest) was started (2 ml/kg bw on day 1 and 3, and 1 ml/kg on days 5, 7 and 9), which led to the eradication of the residual infiltrate and CMV- DNA in the myocardium. After discontinuation of all medication, eosinophilia and asthma recurred so that immunosuppressive treatment was continued.
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Authors | D Gehrke, M Herzum, U Schönian, H H Klein, L Drude, H D Mennel, B Maisch |
Journal | Herz
(Herz)
Vol. 19
Issue 3
Pg. 176-81
(Jun 1994)
ISSN: 0340-9937 [Print] Germany |
Vernacular Title | Eosinophile Endomyokarditis post partum oder Schwangerschaftskardiomyopathie. |
PMID | 7927130
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Immunoglobulins
- Immunoglobulins, Intravenous
- cytomegalovirus-specific hyperimmune globulin
- Azathioprine
- Prednisone
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Topics |
- Adult
- Azathioprine
(administration & dosage)
- Biopsy
- Combined Modality Therapy
- Cytomegalovirus Infections
(diagnosis, drug therapy, pathology)
- Diagnosis, Differential
- Endocardium
(drug effects, pathology)
- Female
- Heart Failure
(diagnosis, drug therapy, pathology)
- Humans
- Hypereosinophilic Syndrome
(diagnosis, drug therapy, pathology)
- Immunoglobulins
(administration & dosage)
- Immunoglobulins, Intravenous
- Myocarditis
(diagnosis, drug therapy, pathology)
- Myocardium
(pathology)
- Opportunistic Infections
(diagnosis, drug therapy, pathology)
- Prednisone
(administration & dosage)
- Pregnancy
- Pregnancy Complications, Cardiovascular
(diagnosis, drug therapy, pathology)
- Puerperal Disorders
(diagnosis, drug therapy, pathology)
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