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Characterization of the effects of scopolamine on the habituation of exploratory activity: differential effects of oxotremorine and physostigmine.

Abstract
1. Habituation was regarded as a difference between exploratory activity measured first (session 1) and that measured second (session 2) in a novel environment. 2. Scopolamine (1.0 mg/kg) significantly increased the horizontal activity in sessions 1 and 2 when administered prior to session 1, resulting in the impairment of habituation. 3. Haloperidol (0.2 mg/kg) inhibited scopolamine-induced hypermotility in session 1, but it did not inhibit the scopolamine-induced impairment of habituation in session 2. 4. The direct cholinergic agonist oxotremorine (0.03 mg/kg), unlike the cholinesterase inhibitor physostigmine, significantly inhibited the scopolamine-induced impairment of habituation in the horizontal and vertical activities. 5. These results suggest that the direct stimulation of cholinergic receptors is more effective for scopolamine-induced amnesia than the indirect stimulation of cholinergic receptors by cholinesterase inhibitors in the habituation task.
AuthorsM Ukai, T Kobayashi, T Kameyama
JournalGeneral pharmacology (Gen Pharmacol) Vol. 25 Issue 3 Pg. 433-8 (May 1994) ISSN: 0306-3623 [Print] England
PMID7926587 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Receptors, Muscarinic
  • Oxotremorine
  • Physostigmine
  • Scopolamine
  • Haloperidol
Topics
  • Amnesia (chemically induced)
  • Animals
  • Exploratory Behavior (drug effects)
  • Habituation, Psychophysiologic (drug effects)
  • Haloperidol (pharmacology)
  • Learning (drug effects)
  • Male
  • Mice
  • Mice, Inbred Strains
  • Motor Activity (drug effects)
  • Oxotremorine (pharmacology)
  • Physostigmine (pharmacology)
  • Receptors, Muscarinic (drug effects)
  • Retention, Psychology (drug effects)
  • Scopolamine (pharmacology)

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