HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Effects of a pyranocoumarin compound isolated from a Chinese medicinal plant on ischemic myocardial dysfunction in anesthetized dogs.

Abstract
A pyranocoumarin compound, 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin (Pd-Ia), isolated from Bai-Hua Qian-Hu, a Chinese medicine, is known to possess a Ca2+ channel antagonist action. We examined the effect of Pd-Ia on cardiohemodynamics and regional myocardial dysfunction after transient ischemia in anesthetized open-chest dogs. I.v. injections of Pd-Ia (0.1-3.0 mg/kg, n = 7) significantly and dose dependently increased coronary blood flow and decreased mean aortic pressure, maximal rate of rise in left ventricular pressure, rate pressure product and systemic vascular resistance, together with a slight increase in heart rate. Diltiazem (0.03-1.00 mg/kg, n = 6) showed effects on the cardiohemodynamics similar to those of Pd-Ia, except for a marked decrease in heart rate. The effects of Pd-Ia on mean aortic pressure and rate pressure product were approximately 10 times less potent than those of diltiazem. In the second experiment, the effect of a 30-min infusion of Pd-Ia (0.15 mg/kg/min) or vehicle on regional myocardial dysfunction was examined in 16 anesthetized dogs subjected to a 15-min occlusion of the left anterior descending coronary artery followed by a 3-h reperfusion. Infusion of Pd-Ia was started 15 min before coronary occlusion. The vehicle caused a decrease in percent segment shortening throughout the reperfusion period (n = 8). However, Pd-Ia at the dose that produced no significant changes in cardiohemodynamics resulted in a marked improvement in percent segment shortening of the ischemic and reperfused myocardium (n = 8, P < 0.05 vs. control group).(ABSTRACT TRUNCATED AT 250 WORDS)
AuthorsT H Chang, H Adachi, N Mori, I Saito, T Okuyama
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 258 Issue 1-2 Pg. 77-84 (Jun 2 1994) ISSN: 0014-2999 [Print] NETHERLANDS
PMID7925602 (Publication Type: Journal Article)
Chemical References
  • Calcium Channel Blockers
  • Coumarins
  • Drugs, Chinese Herbal
  • 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin
  • Diltiazem
Topics
  • Animals
  • Calcium Channel Blockers (pharmacology)
  • Coronary Circulation (drug effects)
  • Coumarins (pharmacology)
  • Diltiazem (administration & dosage, pharmacology)
  • Disease Models, Animal
  • Dogs
  • Dose-Response Relationship, Drug
  • Drugs, Chinese Herbal (therapeutic use)
  • Female
  • Hemodynamics (drug effects)
  • Injections, Intravenous
  • Male
  • Myocardial Ischemia (drug therapy)
  • Vascular Resistance (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: