Immunophenotyping and metastatic localization of breast cancer.

Abstract

Monoclonal antibody SM 92 is involved in the immunophenotype of gastrointestinal and liver cells, SM 43 in ovarian cells, and SM 13 in lung cells. Based on a study of 61 breast adenocarcinoma patients, we found that tumors reacting with SM 92 appear associated with liver metastases, SM 43 with ovarian metastases, and SM 13 with lung metastases. These associations are highly significant. They lend some support to the concept that tumor cells that metastasize tend to go to sites where cells normally have the same surface antigens.

• Authors: J C Gioanni, C Mazeau, E Zanghellini, F Hecht, J Gugenheim, F Crafa, C Granon, M Namer, F Ettore, M Schneider
• Journal: Cancer research (Cancer Res) Vol. 54 Issue 20 Pg. 5464-6 (Oct 15 1994) ISSN: 0008-5472 [Print] United States
• PMID: 7923180 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Antigens, Neoplasm
• Antigens, Surface

Topics

• Antibodies, Monoclonal (immunology)
• Antigens, Neoplasm (immunology)
• Antigens, Surface (immunology)
• Breast Neoplasms (immunology, pathology)
• Female
• Humans
• Immunophenotyping
• Liver Neoplasms (immunology, secondary)
• Lung Neoplasms (immunology, secondary)
• Ovarian Neoplasms (immunology, secondary)