Presence or absence of trisomy 11 is correlated with histologic subtype in congenital mesoblastic nephroma.

Abstract

Fluorescence in situ hybridization utilizing a probe for the alpha satellite repeat sequence on chromosome 11 was used to detect variations in the number of chromosomes 11 in 24 formalin-fixed, paraffin-embedded congenital mesoblastic nephromas. Evidence of trisomy 11 was found in nearly half of the tumors. More importantly, the presence of trisomy 11 was associated with the cellular histologic variant of this tumor.

• Authors: J T Mascarello, T R Cajulis, H F Krous, P M Carpenter
• Journal: Cancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 77 Issue 1 Pg. 50-4 (Oct 1994) ISSN: 0165-4608 [Print] United States
• PMID: 7923083 (Publication Type: Journal Article)

Topics

• Chromosomes, Human, Pair 11
• Humans
• In Situ Hybridization, Fluorescence
• Kidney Neoplasms (genetics, pathology)
• Nephroma, Mesoblastic (complications, genetics, pathology)
• Trisomy