Abstract |
Changes in cerebral microvessel ultrastructure have been reported to occur in Alzheimer's disease (AD). In order to investigate whether these changes are associated with compromised blood-brain transport mechanisms, hippocampal formation sections from AD and age-matched normal brains were immunolabelled with an antibody to the GLUT-1 glucose transporter protein. GLUT-1 immunolabelling of microvessel endothelium was significantly reduced in the AD compared to normal hippocampal formation. Thus, AD is associated with a reduction in cerebral microvessel endothelium glucose transporter content, which may result in decreased glucose availability to the brain.
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Authors | N Horwood, D C Davies |
Journal | Virchows Archiv : an international journal of pathology
(Virchows Arch)
Vol. 425
Issue 1
Pg. 69-72
( 1994)
ISSN: 0945-6317 [Print] Germany |
PMID | 7921416
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glucose Transporter Type 1
- Monosaccharide Transport Proteins
- SLC2A1 protein, human
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Topics |
- Aged
- Aged, 80 and over
- Alzheimer Disease
(metabolism)
- Endothelium, Vascular
(metabolism)
- Female
- Glucose Transporter Type 1
- Hippocampus
(blood supply)
- Humans
- Immunohistochemistry
- Male
- Microcirculation
- Monosaccharide Transport Proteins
(metabolism)
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