HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Value of antifungal prophylaxis with antifungal drugs against oropharyngeal candidiasis in cancer patients.

Abstract
This report focuses on the value of antifungal prophylaxis with antifungal drugs in preventing oropharyngeal candidiasis. Randomised trials comparing non-AIDS immunocompromised patients receiving or not an oral antifungal agent were reviewed. Colonisation of the throat with Candida albicans is a risk factor, principally when cultures for this species of yeasts remain positive after initiation of the prophylaxis. The results of the trials were meta-analysed and we obtained a combined odds ratio for developing oropharyngeal candidiasis of 0.15 when under antifungal prophylaxis (confidence interval at 95%:0.10-0.22, chi 2 statistic of 90.77, P < 0.0001). We conclude that there is a strong beneficial effect of antifungal prophylaxis against the occurrence of oropharyngeal candidiasis. However, up to now, no study has correctly assessed the value of nystatin as a prophylactic agent against oropharyngeal candidiasis.
AuthorsF Meunier, M Paesmans, P Autier
JournalEuropean journal of cancer. Part B, Oral oncology (Eur J Cancer B Oral Oncol) Vol. 30B Issue 3 Pg. 196-9 (May 1994) ISSN: 0964-1955 [Print] ENGLAND
PMID7920166 (Publication Type: Journal Article, Meta-Analysis)
Chemical References
  • Antifungal Agents
Topics
  • Antifungal Agents (therapeutic use)
  • Candida albicans (isolation & purification)
  • Candidiasis (prevention & control)
  • Candidiasis, Oral (prevention & control)
  • Humans
  • Neoplasms (complications)
  • Odds Ratio
  • Opportunistic Infections (prevention & control)
  • Pharyngeal Diseases (prevention & control)
  • Pharynx (microbiology)
  • Prospective Studies
  • Randomized Controlled Trials as Topic
  • Risk Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: