Abstract |
Immunohistochemistry and RT-PCR of basic fibroblast growth factor (bFGF) and one of its receptors (FGFR-I) were performed in pituitary adenomas. Sixty percent of pituitary adenomas showed strong or moderate immunoreactivity to bFGF. The immunoreactivity for FGFR-I in tumor tissues showed positive correlation to that for bFGF (X2 = 6.176, P = 0.0456). Basic FGF-positive cells consisted of pituitary adenoma cells as well as folliculostellate cells and, their distribution was heterogeneous. Expressions of bFGF and FGFR-I were not related to cell proliferation of pituitary adenomas or hormones produced, suggesting that bFGF plays some role other than progression of pituitary adenomas.
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Authors | H Suzui, J A Takahashi, M Fukumoto, N Hashimoto, N Itoh, M Hatanaka, H Kikuchi |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 171
Issue 1-2
Pg. 192-6
(Apr 25 1994)
ISSN: 0304-3940 [Print] Ireland |
PMID | 7916136
(Publication Type: Journal Article)
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Chemical References |
- Antigens, Neoplasm
- Nuclear Proteins
- Proliferating Cell Nuclear Antigen
- RNA, Messenger
- Receptors, Fibroblast Growth Factor
- S100 Proteins
- Fibroblast Growth Factor 2
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Topics |
- Adenoma
(immunology, metabolism)
- Adult
- Aged
- Antigens, Neoplasm
(immunology, metabolism)
- Base Sequence
- Female
- Fibroblast Growth Factor 2
(biosynthesis, immunology, metabolism)
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Molecular Sequence Data
- Nuclear Proteins
(immunology, metabolism)
- Pituitary Neoplasms
(immunology, metabolism)
- Polymerase Chain Reaction
- Proliferating Cell Nuclear Antigen
- RNA, Messenger
(biosynthesis)
- Receptors, Fibroblast Growth Factor
(biosynthesis, immunology, metabolism)
- S100 Proteins
(immunology, metabolism)
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