Abstract |
The effect of oral aspirin on the healing rate of chronic venous leg ulcers was compared with that of placebo in a double-blind randomised trial. 20 subjects with chronic venous leg ulcers were randomised to daily enteric-coated aspirin 300 mg or placebo, and standardised compression bandaging. 4 months of treatment achieved ulcer healing in 38% of the patients receiving aspirin compared with 0% of those receiving placebo (p < 0.007). 52% of the aspirin-treated group showed significant reduction in ulcer size compared with 26% of placebo recipients (p < 0.007). Reduction in ulcer surface area was significantly better in the aspirin-treated group at 2 (p < 0.01) and 4 months (p < 0.002) compared with that in the placebo group.
|
Authors | A M Layton, S H Ibbotson, J A Davies, M J Goodfield |
Journal | Lancet (London, England)
(Lancet)
Vol. 344
Issue 8916
Pg. 164-5
(Jul 16 1994)
ISSN: 0140-6736 [Print] England |
PMID | 7912767
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
|
Chemical References |
|
Topics |
- Administration, Oral
- Aged
- Aged, 80 and over
- Aspirin
(therapeutic use)
- Bandages
- Chronic Disease
- Combined Modality Therapy
- Female
- Humans
- Male
- Middle Aged
- Varicose Ulcer
(drug therapy, therapy)
|