Abstract | BACKGROUND: Neuromuscular blocking drugs cause excitement and seizures when introduced into the central nervous system. We examined the possibility that these drugs produce paradoxical activation of acetylcholine or glutamate receptors, the chief types of brain receptors involved in excitatory neurotransmission. METHODS: RESULTS: CONCLUSIONS:
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Authors | C Cardone, J Szenohradszky, S Yost, P E Bickler |
Journal | Anesthesiology
(Anesthesiology)
Vol. 80
Issue 5
Pg. 1155-61; discussion 29A
(May 1994)
ISSN: 0003-3022 [Print] United States |
PMID | 7912481
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Convulsants
- Glutamates
- Isoquinolines
- Neuromuscular Nondepolarizing Agents
- Neurotoxins
- Receptors, Nicotinic
- Atracurium
- Glutamic Acid
- Phenytoin
- N-Methylaspartate
- Nicotine
- Vecuronium Bromide
- Enflurane
- laudanosine
- Pancuronium
- Acetylcholine
- Kainic Acid
- Calcium
- Tubocurarine
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Topics |
- Acetylcholine
(pharmacology)
- Anesthesia, General
- Animals
- Atracurium
(toxicity)
- Brain
(drug effects, metabolism, physiology)
- Calcium
(metabolism)
- Convulsants
(toxicity)
- Dose-Response Relationship, Drug
- Enflurane
- Female
- Glutamates
(toxicity)
- Glutamic Acid
- In Vitro Techniques
- Isoquinolines
(toxicity)
- Kainic Acid
(toxicity)
- Male
- N-Methylaspartate
(toxicity)
- Neuromuscular Nondepolarizing Agents
(toxicity)
- Neurotoxins
(toxicity)
- Nicotine
(pharmacology)
- Pancuronium
(toxicity)
- Phenytoin
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Receptors, Nicotinic
(drug effects, physiology)
- Time Factors
- Tubocurarine
(toxicity)
- Vecuronium Bromide
(toxicity)
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