Effects of naftidrofuryl oxalate, a 5-HT2 antagonist, on neuronal damage and local cerebral blood flow following transient cerebral ischemia in gerbils.

Abstract

Effects of naftidrofuryl oxalate (naftidrofuryl), a 5-HT2 antagonist, on neuronal damage and local cerebral blood flow was examined in a gerbil model of transient forebrain ischemia. Effect of ketanserin tartrate (ketanserin), another 5-HT2 antagonist, on neuronal damage was also examined. Pretreatment with naftidrofuryl or ketanserin prevented hippocampal CA1 neuronal loss after 5 min of transient ischemia. Naftidrofuryl did not improve hippocampal blood flow during and 1 h after transient ischemia determined by [14C]iodoantipyrine autoradiography but increased blood flow in the caudate-putamen 1 h after transient ischemia. The results show that: (1) the 5-HT2 antagonists protect against hippocampal CA1 neuronal damage; and (2) the protective effect of naftidrofuryl may not be caused by a hemodynamic mechanism but by a direct inhibitory neuromodulation via 5-HT2 antagonistic action.

• Authors: H Fujikura, H Kato, T Araki, H Ban, Y Hasegawa, K Kogure
• Journal: Brain research (Brain Res) Vol. 636 Issue 1 Pg. 103-6 (Feb 04 1994) ISSN: 0006-8993 [Print] Netherlands
• PMID: 7908849 (Publication Type: Journal Article)

Chemical References

• Histamine H2 Antagonists
• Nafronyl
• Ketanserin

Topics

• Animals
• Autoradiography
• Brain (pathology)
• Cerebrovascular Circulation (drug effects)
• Gerbillinae
• Hippocampus (blood supply, pathology)
• Histamine H2 Antagonists (pharmacology)
• Ischemic Attack, Transient (pathology)
• Ketanserin (pharmacology)
• Male
• Nafronyl (pharmacology)
• Neurons (drug effects)
• Regional Blood Flow (drug effects)