Treatment of polycystic ovarian disease during adolescence with ethinylestradiol/cyproterone acetate versus a D-Tr-6-LHRH analog.

Abstract

OBJECTIVE:

This study was undertaken to compare the clinical and endocrinological results of two kinds of treatment on adolescents with polycystic ovarian disease (PCOD).

METHOD:

Forty-five adolescents with PCOD were randomly allocated into two groups, treated either with ethinylestradiol (EE)/cyproterone acetate (group A) or the GnRH analog D-Tr-6-LHRH (group B).

RESULT:

No significant changes were detected on the body mass index and waist-hip circumference. A significant improvement of hirsutism was noticed in both groups of patients. A normal menstrual period was recorded in group A adolescents while all group B patients became amenorrheic. A favorable decrease of ovarian volume was detected in both groups. LH/FSH ratio and delta 4-androstenedione serum levels were found significantly reduced in both groups in comparison to pre-treatment levels. The comparison between the two groups, after 6 months, showed significantly lower values of LH/FSH ratio in group B cases.

CONCLUSION:

Both forms of treatment are safe and effective to a various degree for the management of PCOD adolescents.

• Authors: G Creatsas, E Hassan, E Deligeoroglou, G Tolis, D Aravantinos
• Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 42 Issue 2 Pg. 147-53 (Aug 1993) ISSN: 0020-7292 [Print] United States
• PMID: 7901064 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Delayed-Action Preparations
• Sex Hormone-Binding Globulin
• Triptorelin Pamoate
• Testosterone
• Androstenedione
• Ethinyl Estradiol
• Dehydroepiandrosterone
• Cyproterone Acetate
• Dehydroepiandrosterone Sulfate
• Prolactin
• Luteinizing Hormone
• Follicle Stimulating Hormone
• Dinoprostone

Topics

• Adolescent
• Androstenedione (blood)
• Cyproterone Acetate (therapeutic use)
• Dehydroepiandrosterone (analogs & derivatives, blood)
• Dehydroepiandrosterone Sulfate
• Delayed-Action Preparations
• Dinoprostone (blood)
• Drug Therapy, Combination
• Ethinyl Estradiol (therapeutic use)
• Female
• Follicle Stimulating Hormone (blood)
• Humans
• Luteinizing Hormone (blood)
• Polycystic Ovary Syndrome (blood, drug therapy)
• Prolactin (blood)
• Prospective Studies
• Sex Hormone-Binding Globulin (analysis)
• Testosterone (blood)
• Triptorelin Pamoate (therapeutic use)