Nitrendipine and superoxide dismutase in ischemic renal injury.

Abstract

The effect of the Ca entry blocker nitrendipine, the antioxidant superoxide dismutase (SOD), and a combination of nitrendipine and superoxide dismutase on postischemic renal function was studied in four groups (n = 24) of rats. The rats in group 1 (n = 6) were the ischemic control and received 10 mL of 0.9% NaCl. Group II (n = 6) received SOD 7.0 mg/kg. Group III (n = 6) received nitrendipine 1 mg/kg. Group IV (n = 6) received nitrendipine 1 mg/kg and SOD 7 mg/kg. After administration, both kidneys were rendered ischemic by cross-clamping the renal vessels for 60 min. Comparison of 24-h creatinine clearance (CCr) for 3 days after reversal of ischemia revealed: (a) nitrendipine alone was the most effective in preserving renal function (p < .05); (b) SOD provided some degree of improvement, but only on day 3 (p < .05); (c) a similar result was detected using a combination of nitrendipine and SOD (p < .05); (d) there was no significant difference between SOD and nitrendipine nor between SOD and the combination of nitrendipine/SOD; (e) there was a significant improvement with nitrendipine when compared to the combination of nitrendipine/SOD (p < .05).

• Authors: W K Jacobsen, R M Schell, J S Matsumura, D J Cole, G R Stier, R D Martin, B L Fandrich
• Journal: Renal failure (Ren Fail) Vol. 16 Issue 6 Pg. 697-705 (Nov 1994) ISSN: 0886-022X [Print] England
• PMID: 7899581 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Nitrendipine
• Creatinine
• Superoxide Dismutase

Topics

• Acute Kidney Injury (drug therapy, etiology, physiopathology)
• Animals
• Creatinine (blood, urine)
• Drug Therapy, Combination
• Ischemia (drug therapy, physiopathology)
• Kidney (blood supply, drug effects, physiopathology)
• Male
• Nitrendipine (therapeutic use)
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Superoxide Dismutase (therapeutic use)