Abstract | OBJECTIVES: BACKGROUND: METHODS: RESULTS:
FR139317 lowered pulmonary artery and systemic arterial pressures in both pulmonary hypertensive and control beagles, with a significantly greater effect on pulmonary artery pressure in pulmonary hypertensive dogs. RES-701-1 tended to increase pulmonary artery pressure only in pulmonary hypertensive beagles. Nitroglycerin depressed pulmonary artery and systemic arterial tone equally well in control and pulmonary hypertensive animals. Prostaglandin E1 produced a greater decrease in systemic arterial pressure in pulmonary hypertensive than in normal beagles despite having the same effect on pulmonary artery pressure in both. CONCLUSIONS: ETA receptor antagonists decrease pulmonary artery pressure in a beagle model and may therefore be clinically useful for treatment of pulmonary hypertension.
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Authors | M Okada, C Yamashita, M Okada, K Okada |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 25
Issue 5
Pg. 1213-7
(Apr 1995)
ISSN: 0735-1097 [Print] United States |
PMID | 7897136
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Azepines
- Endothelin Receptor Antagonists
- Indoles
- Peptides, Cyclic
- FR 139317
- RES 701-1
- monocrotaline pyrrole
- Monocrotaline
- Alprostadil
- Nitroglycerin
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Topics |
- Alprostadil
(pharmacology)
- Animals
- Azepines
(administration & dosage, pharmacology)
- Dogs
- Endothelin Receptor Antagonists
- Hemodynamics
(drug effects)
- Hypertension, Pulmonary
(chemically induced, drug therapy, physiopathology)
- Indoles
(administration & dosage, pharmacology)
- Monocrotaline
(analogs & derivatives)
- Nitroglycerin
(pharmacology)
- Peptides, Cyclic
(administration & dosage, pharmacology)
- Pulmonary Circulation
(drug effects)
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