[Treatment of external ano-genital condylomata with 0.5% podophyllotoxin].

Abstract

There are several possible protocols for the treatment of ano-genital condylomata. In this study, the efficacy of podophyllotoxin (0.5%) was assessed. The authors observed a recovery rate at 1 month of 81% in cases of condylomata of the balano-preputial and vulvar mucous membranes, a rate of 67% in condylomata of the keratinized tissues and 63% in those of the anal margin. Response to treatment is also dependent on the morphology of the lesion; regression was observed in 78% of cases of condylomata acuminata and in 57% of cases of endophytic condylomata. The side effects were local and consisted of erosion in 20% of cases. The efficacy of treatment was, amongst other things, analysed according to the recurrence of the infection at one month, which occurred in 16% of cases affecting mucous membranes. In the therapeutic arsenal for the treatment of condylomata, podophyllotoxin 0.5% is a first line treatment for condylomata acuminata of the genital mucous membranes.

• Authors: O Aynaud, P Tranbaloc
• Journal: Contraception, fertilite, sexualite (1992) (Contracept Fertil Sex) Vol. 23 Issue 2 Pg. 127-30 (Feb 1995) ISSN: 1165-1083 [Print] France
• Vernacular Title: Traitement des condylomes ano-génitaux externes par podophyllotoxine à 0.5%.
• PMID: 7894544 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Podophyllotoxin

Topics

• Adult
• Anus Diseases (drug therapy, pathology)
• Condylomata Acuminata (drug therapy, pathology)
• Female
• Humans
• Male
• Penile Diseases (drug therapy, pathology)
• Podophyllotoxin (therapeutic use)
• Prospective Studies
• Recurrence
• Treatment Outcome
• Vulvar Diseases (drug therapy, pathology)