Anti-GOR in hepatitis D: specific association with hepatitis C virus superinfection.

Abstract

A group of 113 patients with chronic hepatitis D was investigated for the presence of anti-GOR and liver kidney microsomal antibodies. Eight patients were anti-GOR positive and also positive for hepatitis C virus-infection. In sera from 16 patients liver-kidney microsomal antibodies were detectable by immunofluorescence. They were classified as LKM-3 due to their fluorescence pattern. Two of the LKM-3-positive sera were also anti-hepatitis C virus and anti-human immunodeficiency virus positive. None of these patients were positive for anti-GOR. Fourteen sera from LKM-3-positive patients reacted in Western blot with a microsomal protein at 55 kDa that differs from the 50-kDa LKM-1 (cytochrome P450IID6) antigen. Our studies demonstrate that hepatitis D virus itself does not induce an autoimmune reaction against the GOR antigen and that autoimmunity to the LKM-3 antigen induced by hepatitis D virus infection does not correlated with anti-GOR. These studies support the specificity of the anti-GOR response for hepatitis C virus infection.

• Authors: M Durazzo, G Michel, T Philipp, H B Braun, B Luttig, M Rizzetto, M Manns
• Journal: International journal of clinical & laboratory research (Int J Clin Lab Res) Vol. 24 Issue 4 Pg. 227-9 ( 1994) ISSN: 0940-5437 [Print] Germany
• PMID: 7894050 (Publication Type: Journal Article)

Chemical References

• Autoantibodies
• Biomarkers
• Hepatitis Antibodies
• Immunoglobulin G

Topics

• Autoantibodies (analysis)
• Base Sequence
• Biomarkers (analysis)
• Hepacivirus (immunology)
• Hepatitis Antibodies (analysis)
• Hepatitis C (immunology)
• Hepatitis D (immunology)
• Humans
• Immunoglobulin G (analysis)
• Molecular Sequence Data
• Superinfection (immunology)