Marchiafava-Bignami disease with dementia: severe cerebral metabolic depression revealed by PET.

Abstract

The Cerebral Metabolic Rate of Glucose (CMRGlu) was measured with positron emission tomography and 18F-FDG in a patient with Marchiafava-Bignami Disease (MBD)-related dementia. Despite MRI evidence of lesions essentially limited to the corpus callosum (CC), but consistent with the cognitive pattern of cortical dementia, the CMRGlu was markedly reduced in the frontal and temporo-parieto-occipital association cortices. Disruption of cortico-cortical networks crossing the CC presumably contributed to, but may not in and by itself explain, the severity of the clinical-metabolic findings in this patient. An additional role could be played by microscopic white matter lesions and/or neocortical neuronal loss, which have been occasionally observed in post-mortem studies of MBD patients.

• Authors: S Pappata, H Chabriat, M Levasseur, F Legault-Demare, J C Baron
• Journal: Journal of neural transmission. Parkinson's disease and dementia section (J Neural Transm Park Dis Dement Sect) Vol. 8 Issue 1-2 Pg. 131-7 ( 1994) ISSN: 0936-3076 [Print] Austria
• PMID: 7893375 (Publication Type: Case Reports, Journal Article)

Chemical References

• Glucose

Topics

• Adult
• Alcoholism (diagnostic imaging, physiopathology)
• Animals
• Brain (diagnostic imaging, metabolism)
• Cerebral Cortex (diagnostic imaging, metabolism)
• Corpus Callosum (diagnostic imaging, physiopathology)
• Dementia (diagnostic imaging, physiopathology)
• Glucose (metabolism)
• Humans
• Magnetic Resonance Imaging
• Tomography, Emission-Computed