Clinical pharmacokinetics of pancuronium bromide.

Abstract

Plasma concentrations of pancuronium bromide have been studied in seven surgical patients following a 6 mg intravenous bolus injection of the drug for neuromuscular blockade. Concurrently, evoked muscle twitch response was monitored for each patient as a measure of the pharmacodynamic effect of the drug. The plasma decay curve for pancuronium was found to be biphasic and after rigorous statistical analysis the data were interpreted according to a 2-compartment open model. The half-life of the beta-phase varied between 89.5 and 161.5 min. The apparent volume of distribution of the central compartment ranged from 62.9 to145.5 ml/kg and the plasma clearance from 57.6 to 187.3 ml/min. At the first sign of recovery from neuro-muscular blockade the mean pancuronium plasma level was found to be 0.218 mcg/ml. The mean duration of action as measured from time of onset of paralysis to 20% recovery was 83.4 min with the plasma level at 20% being 0.169 mcg/ml corresponding to 45.4% of dose remaining to be eliminated from the body.

• Authors: A A Somogyi, C A Shanks, E J Triggs
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 10 Issue 5 Pg. 367-72 (Sep 30 1976) ISSN: 0031-6970 [Print] Germany
• PMID: 789085 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Pancuronium

Topics

• Adult
• Aged
• Anesthesia, Intravenous
• Clinical Trials as Topic
• Female
• Half-Life
• Humans
• Male
• Middle Aged
• Models, Biological
• Pancuronium (blood, metabolism, pharmacology)
• Surgical Procedures, Operative