Fish protein-rich diet attenuates hypertension induced by dietary NG-nitro-L-arginine in normotensive Wistar-Kyoto rats.

Abstract

1. Dietary 0.023% NG-nitro-L-arginine (L-NNA), an inhibitor of nitric oxide synthesis, induced hypertension in normotensive Wistar-Kyoto rats (WKY). This hypertension was significantly attenuated in WKY given a fish protein-rich diet. 2. The supplement of 2% L-arginine given in a standard diet or a diet containing 3% taurine for drinking did not significantly affect the development of hypertension induced by L-NNA in WKY. 3. WKY which received the standard diet mixed with 10% urea and 0.023% L-NNA had significantly attenuated hypertension compared with WKY receiving the standard diet mixed with 10% kaolin and 0.023% L-NNA. 4. These results suggest that the attenuation of hypertension in L-NNA-treated WKY rats given a fish protein rich diet may be partly caused by urea, a metabolic end-product of protein.

• Authors: O G Gutierrez Jr, K Ikeda, Y Nara, G U Deguan, Y Yamori
• Journal: Clinical and experimental pharmacology & physiology (Clin Exp Pharmacol Physiol) Vol. 21 Issue 11 Pg. 875-9 (Nov 1994) ISSN: 0305-1870 [Print] Australia
• PMID: 7882578 (Publication Type: Journal Article)

Chemical References

• Dietary Proteins
• Urea
• Arginine

Topics

• Animals
• Arginine (toxicity)
• Blood Pressure (drug effects)
• Dietary Proteins (therapeutic use)
• Fishes
• Heart Rate (drug effects)
• Hypertension (classification, therapy)
• Male
• Rats
• Rats, Inbred WKY
• Urea (pharmacology)