Use of ketorolac in the prevention of suxamethonium myalgia.

Abstract

We have evaluated the effect of ketorolac in the prevention of suxamethonium myalgia. Sixty ASA I patients who presented for extraction of wisdom teeth as day cases were allocated randomly to one of three equal groups. Patients received either 0.9% saline (placebo), atracurium 0.05 mg kg-1 i.v. or ketorolac 10 mg i.v., 3 min before induction of anaesthesia. Follow-up postal questionnaires (97% response rate) at 48 h showed no reduction in the incidence of myalgia after ketorolac pretreatment compared with saline. The use of atracurium reduced the incidence of myalgia by 60% (P < 0.001) and the severity of fasciculations (P < 0.001). There was no difference in the severity of fasciculations between the saline and ketorolac groups. Intubating conditions were comparable in the three groups.

• Authors: C G Leeson-Payne, J M Nicoll, G J Hobbs
• Journal: British journal of anaesthesia (Br J Anaesth) Vol. 73 Issue 6 Pg. 788-90 (Dec 1994) ISSN: 0007-0912 [Print] England
• PMID: 7880667 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Analgesics
• Atracurium
• Tolmetin
• Succinylcholine
• Ketorolac

Topics

• Adolescent
• Adult
• Analgesics (therapeutic use)
• Atracurium (therapeutic use)
• Female
• Follow-Up Studies
• Humans
• Ketorolac
• Male
• Middle Aged
• Muscular Diseases (prevention & control)
• Pain (chemically induced, prevention & control)
• Premedication
• Succinylcholine (adverse effects)
• Tolmetin (analogs & derivatives, therapeutic use)
• Tooth Extraction